CLASSIFICATION
Anxiolytic Peptide
ACNE
No
WATER RETENTION
No
HBR
No
HEPATOTOXICITY
No
AROMATIZATION
No
MANUFACTURER
Deus Medical
LAB TEST
See Document
WAREHOUSE
EU Warehouse 2
SUBSTANCE
Selank Anxiolytic Peptide
As biotechnology advances, the spotlight shines on innovative biologically active compounds known for enhancing cognitive functions, including the celebrated nootropic, Selank. Previously referred to as ?TP-7,? Selank is a synthetic peptide, a compact, artificially crafted protein that stands at the forefront of anti-anxiety solutions.
Heralded as an effective "anti-anxiety" agent, Selank is also believed to facilitate learning and elevate energy levels without the risk of negative side effects or dependency. Developed collaboratively by the Institute of Molecular Genetics (Russian Academy of Sciences) and the V.V. Zakusov Research Institute of Pharmacology, Selank was designed by combining a peptide sequence from tuftsin?a naturally occurring peptide integral to the antibody IgG?enhanced for molecular stability.
Research reveals that both tuftsin and Selank can lower anxiety and boost serotonin levels in animal studies, with Selank demonstrating superior efficacy. While Selank has gained approval in Russia for treating generalized anxiety disorder (GAD) and as a nootropic, it is not sanctioned by the FDA. Nevertheless, it remains accessible in various countries as a "nutritional supplement."
Mechanism of Action for Selank
Though the mechanisms of Selank's action are not entirely defined, it is believed to stabilize enkephalins in the bloodstream?natural peptides that may help alleviate stress responses. However, some studies have not confirmed enkephalin stabilization post-Selank dosing, raising questions about its anti-anxiety effects.
Additionally, Selank may interact with GABA receptors, which are linked to sedative effects. Studies have shown that Selank treatment can enhance activity in GABA-dependent inhibitory neurons, resulting in reduced overall brain activity akin to sedation.
Moreover, increases in BDNF, a crucial neurotropic factor associated with learning and memory, have been observed, potentially underpinning Selank's cognitive benefits. Notably, Selank appears to influence neurotransmitter levels?norepinephrine, dopamine, and serotonin?each integral to motivation, focus, and pleasure.
However, the nuances of Selank's effects remain complex, with varying results reported regarding its impact on neurotransmitter levels, highlighting the need for clarity through ongoing research.
Potential Benefits
In preliminary clinical trials involving 62 participants, those who received Selank reported a reduction in anxiety symptoms, particularly individuals with existing anxiety disorders. Similar results emerged from a study with 60 patients experiencing anxiety and phobias, with benefits lasting up to a week post-treatment. In another study of 70 anxiety patients, Selank was found to enhance the effects of phenazepam, an anti-anxiety medication, while minimizing side effects like drowsiness and memory loss. Animal research has also confirmed Selank's ability to ease anxiety in mice, especially those with heightened initial anxiety levels.
Anxiety
While evidence is still emerging, these findings suggest Selank may help alleviate anxiety. However, further investigation is essential to confirm its safety and efficacy in humans. If you are battling anxiety, it's crucial to consult a healthcare professional before considering Selank, ensuring adherence to their recommendations over self-medication with supplements.
Memory
In a 30-day trial involving rats, Selank appeared to aid in stabilizing memory traces, potentially enhancing memory retention. However, the methods used to evaluate memory are not fully defined, and further studies are necessary to determine Selank's effects and safety in humans.
Recovery from Brain Damage
In studies, Selank has shown promise in restoring normal brain activity in rats with toxin-induced brain damage.
Depression
Preliminary animal studies suggest that Selank effectively reduces depressive symptoms in mice, with lower doses yielding better results than higher ones.
Antioxidant Activity in the Liver
Initial research indicated that Selank injections elevated antioxidant levels in the livers of stressed mice.
Blood Flow
In a study involving sedated cats, Selank was shown to reduce blood pressure by approximately 30% for three minutes and increase cerebral blood flow by about 24% for ten minutes. While encouraging, these transient effects warrant further exploration to determine their clinical significance.
Alcohol Withdrawal
Research indicates that Selank may mitigate anxiety during alcohol withdrawal, as evidenced by a study where rats treated with Selank experienced reduced anxiety after a prolonged period of high ethanol consumption.
Weight Gain Prevention and Cholesterol Reduction
Animal studies revealed that Selank treatment led to 35% less weight gain and significant reductions in total cholesterol and blood glucose levels in rats on a high-fat diet.
Cancer
In preliminary studies, Selank appeared to slow tumor growth in mice with breast cancer. However, these findings are still in their infancy and should not be interpreted as a viable cancer treatment; further research is essential.
Inflammation in the Spleen
Following Selank treatment, mice exhibited increased levels of inflammatory response genes in their spleens, suggesting potential protective effects against inflammation.
Ulcers
Animal studies indicate that Selank may reduce stomach ulcer size, potentially by enhancing lymph flow to the stomach. However, comprehensive human research is required to affirm these findings.
Immune Function
Selank has been associated with increased IL-6 levels in blood cells from depressed patients and may stimulate interferon release, molecules that combat viral infections. However, its antiviral efficacy is still under scrutiny due to mixed results in animal studies.