Ultima-Follistion 344 1mg

MANUFACTURER Ultima Pharmaceuticals - USA
WAREHOUSE USA Warehouse 5
SUBSTANCE Follistatin

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Follistatin is a powerful single-chain gonadal protein that plays an essential role in suppressing the release of follicle-stimulating hormone (FSH). This remarkable protein is encoded by the FST gene, yielding two isoforms?FST317 and FST344?composed of 317 and 344 amino acids, respectively, thanks to alternative splicing of precursor mRNA. By binding directly to activin, follistatin acts as a key antagonist, effectively inhibiting the production and secretion of pituitary FSH.

Ongoing research highlights follistatin's significant role in regulating muscle growth. Studies on mice reveal its antagonistic action against myostatin (GDF-8), a member of the TGF superfamily known for limiting excess muscle development. Pioneering work by Lee & McPherron demonstrated that either eliminating GDF-8 genetically (using knockout mice) or increasing follistatin levels led to remarkable muscle mass gains. Additionally, a 2009 study involving macaque monkeys showcased that gene therapy aimed at regulating follistatin resulted in increased muscle growth and enhanced strength.